The San Fransisco street where the boy reporter interviews Louis. It cuts accross San Fransisco, terminating in the Castro District, a gay neighbourhood. Locations have great significance for Rice, and Divisadero Street evolves in its meaning as the Chronicles develop.

Rice had visited a small radio station on Divisadero when she was lengthening a short story called "Interview with the Vampire." She had noted on it the tragic contrast of tall, narrow Victorian houses sitting in the midst of contemporary squalor and gloom; bars with flashing neon signs contrasted sharply with the deterioating gingerbread lace. "What was working for me as writer," she said, "was an intuitive sense of the utter gloom, this deep urban Gothic that used to be captured years ago in comic books." She wanted to set her story in an old Victorian building with dingy, sparsely furnished rooms, to emphasise how the vampire telling his supernatural tale was out of place in the twentieth century; like the house, he, too, was a relic left over from bygone times. A house set so near the street would also provide modern textures to the background, such as car headlights and traffic noise, thus retaining the contrast as Louis spoke. When Rice went back to write her story, her memory of a specific house with a stained glass window permeated the first scene. Louis remains in this house during the whole story, then returns to it after IV is published.